Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia
Ana J. Chucair‐Elliott, Sarah R. Ocañas, David R. Stanford, Victor A. Ansere, Kyla B. Buettner, Hunter L. Porter, Nicole L. Eliason, Justin J. Reid, Amanda Lea Sharpe, Michael B. Stout, Michael J. Beckstead, Benjamin F. Miller, Arlan G Richardson, Willard M. Freeman
The paper introduces a NuTRAP method to isolate RNA and DNA from specific CNS cell types, revealing cell type-specific epigenetic and transcriptomic differences in microglia and astrocytes.
Communications Biology · Nov 19, 2020Peer-reviewedNeuroscience