David Aponte-Diaz

This study identifies a fold switch in ONNV nsP4 that regulates its conformation, RNA binding, and polymerase activity through proteolytic cleavage and fold switching.

This study identifies a minimal functional precursor of CHIKV nsP4 required for RNA synthesis and shows cleavage by nsP2 protease is essential for replication.

This study identifies a poliovirus nonstructural protein 3CD with an LIR motif critical for non-lytic spread via autophagosome incorporation and trafficking.

The paper investigates PV-induced organelles by analyzing spatiotemporal dynamics of PI4P and membrane structures, suggesting distinct organelles for genome replication and virus assembly.