Kotaro Fujii

The paper shows that Reh1 detects defective ribosomes by sensing the absence of nascent peptides, leading to ubiquitination of Rpl19 and triggering nonfunctional ribosome decay.

The paper shows translation fidelity varies across cell types and developmental stages, with brain and muscle having the highest accuracy, and demonstrates its role in neuronal differentiation.

RAPIDASH enriches ribosome-associated proteins from diverse samples, revealing their roles in neurodevelopment and immune response.

This study develops PERSIST-seq and In-line-seq to optimize mRNA stability and translation, finding that in-cell stability is more critical than ribosome load for protein output.