Author

Kathrin Leppek

University of BonnORCID 0000-0002-8012-8076Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1

Frequent Co-Authors

Adele XuiD· 1 shared Aiswarya GopaliD· 1 shared Alexander Niklas WirthiD· 1 shared Alicia SolórzanoiD· 1 shared Amina NoraddiniD· 1 shared Anders Henrik LundiD· 1 shared Andrew M. WatkinsiD· 1 shared Anna RighettiiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMolecular Biology

Adele XuORCID

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Author profile →

3 papers

Recent·Most cited

Eukaryotic tRNA ligases mediate RNA break repair

Alexander Niklas Wirth, Isabel S. Naarmann‐de Vries, Anne Marie Pinnen, Aiswarya Gopal, Anna Righetti, Kathrin Leppek, Christoph Dieterich, Jirka Peschek

This study shows that eukaryotic tRNA ligases repair RNA breaks in ribosomes and other RNPs, restoring translational activity and maintaining transcriptome integrity.

bioRxiv · May 27, 2026 · PreprintBiochemistry

Synthetic circRNAs employ IRES activity for translation in cells and in cell-free translation systems

Philipp Koch, Frederic Schrøder Arendrup, Chaehee Lim, Samyukta Narayanan, Amina Noraddin, Massimiliano Clamer, Anders Henrik Lund, Chun‐Kan Chen, Kathrin Leppek

The paper examines the translation efficiency of synthetic circRNAs using different IRESes in human cells and in vitro systems, finding that several IRESes effectively drive circRNA translation.

bioRxiv · May 21, 2026 · PreprintBiochemistry

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

Kathrin Leppek, Gun Woo Byeon, Wipapat Kladwang, Hannah K. Wayment-Steele, Craig H. Kerr, Adele Xu, Do Soon Kim, Ved V. Topkar, Christian A. Choe, Daphna Rothschild, Gerald C. Tiu, Roger Wellington-Oguri, Kotaro Fujii, Eesha Sharma, Andrew M. Watkins, , Rhiju Das

This study develops PERSIST-seq and In-line-seq to optimize mRNA stability and translation, finding that in-cell stability is more critical than ribosome load for protein output.

Nature Communications · Mar 22, 2022Peer-reviewedMolecular Biology