Michael France

Exposure to Antibiotics Modifies the Immune Profiles of Bacterial Extracellular Vesicles from Common Vaginal Anaerobes

This study shows antibiotics alter immune profiles of bacterial extracellular vesicles from vaginal anaerobes, potentially causing inflammation and dysbiosis.

A Syntenic Pangenome of Gardnerella Reveals Novel Plasmids and Phage, Taxonomic Boundaries, and Species-Level Stratification of Metabolic and Virulence Potential

This study constructs a syntenic pangenome of Gardnerella, revealing new plasmids, taxonomic boundaries, and species-level differences in metabolic and virulence traits.

Resource landscape shapes the composition and stability of the human vaginal microbiota

This study introduces a mathematical model to explore how nutritional resources shape the composition and stability of the human vaginal microbiota, showing that exclusive access to certain nutrients correlates with bacterial vaginosis dominance.

Immunosuppressants Rewire the Gut Microbiome-Alloimmune Axis Through Time-Dependent and Tissue-Specific Mechanisms

This study examines how four immunosuppressants alter the gut microbiome and immune responses over time, revealing drug-specific and tissue-dependent effects on microbial composition and lymphoid architecture.

Vitamin B2 Production by Vaginal Lactobacilli Promotes Symbiosis

This study identifies riboflavin production by vaginal lactobacilli and shows its role in modulating host immune responses and redox balance.

kSanity: A k-mer based application forprecision bacterial strain detection andquantification

kSanity detects and quantifies bacterial strains in metagenomic data using k-mer matching, showing precision even at low coverage.

Rapamycin Immunomodulation Utilizes Time-Dependent Alterations of Lymph Node Architecture, Leukocyte Trafficking, and Gut Microbiome

This study investigates how rapamycin modulates lymph node architecture, leukocyte trafficking, and gut microbiome over time, revealing a novel mechanism of immunosuppression.

VIRGO2: Unveiling the Functional and Ecological Complexity of the Vaginal Microbiome with an Enhanced Non-Redundant Gene Catalog

This study introduces VIRGO2, an enhanced gene catalog for the vaginal microbiome, revealing new bacterial species, mycobiome features, and gene expression patterns.

High-resolution functional description of vaginal microbiomes in health and disease

The paper develops metagenomic community state types (mgCSTs) to describe vaginal microbiomes by integrating composition and function, identifying associations with health outcomes and functional capabilities.

VIRGO, a comprehensive non-redundant gene catalog, reveals extensive within community intraspecies diversity in the human vagina

The paper introduces VIRGO, a gene catalog for the vaginal microbiome, revealing high intraspecies diversity in vaginal communities.