Ryan D. Huff

Engineering a Multilayer Microfluidic Airway-On-A-Chip with Tunable GelMA Hydrogel for Physiologically Relevant Aerosol Exposure Studies

This paper develops a microfluidic airway-on-a-chip with GelMA hydrogel for studying smoke-induced airway responses, showing inflammatory and fibrotic effects from TGF-β1 and wood smoke exposure.

Woodsmoke and Diesel Exhaust: Distinct Transcriptomic Profiles in the Human Airway Epithelium

This study compares the transcriptomic effects of woodsmoke and diesel exhaust on human airway epithelial cells, showing distinct gene expression changes and pathways affected.

Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

The impact of cigarette smoke exposure, and COPD or asthma status on ABC transporter gene expression in human airway epithelial cells

The paper analyzes ABC transporter gene expression in human airway epithelial cells under cigarette smoke, COPD, and asthma conditions, identifying differentially expressed transporters and validating findings with an in vitro model.

A comparative analysis of cannabis and tobacco smoke exposure on human airway epithelial cell gene expression, immune phenotype, and response to formoterol and budesonide treatment

This study compares the effects of cannabis and tobacco smoke on human airway epithelial cells, showing similar impairments in barrier function and antiviral responses, with no benefit from formoterol/budesonide treatment.