Ingrid E. Lundberg

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

The study identifies distinct metabolic profiles in extracellular vesicles from sarcoidosis patients compared to anti-synthetase syndrome and healthy controls using metabolomic analysis.

The paper identifies anti-MDA5 monoclonal antibodies from DM patients, showing they target distinct epitopes within the helicase domains of MDA5.

This study shows that serum from IIM patients reduces skeletal muscle force, but isolated IgG does not, suggesting humoral factors directly cause muscle weakness.