Vijay Joshua

Patient-derived anti-MDA5 antibodies bind MDA5 filaments in two germline-encoded modes; only filament immune complexes activate innate immunity, with LINE-derived dsRNA scaffolding circulating filaments in patient plasma.

The paper identifies anti-MDA5 monoclonal antibodies from DM patients, showing they target distinct epitopes within the helicase domains of MDA5.

This study shows that disrupting microglial TGF-β signaling causes region-specific demyelination in the spinal cord, with severity varying by age and sex.

This study shows that human amniotic epithelial cells reduce CNS inflammation in MS by inducing immunosuppressive myeloid cells and resolving inflammation.

This study characterizes the HLA-DR immunopeptidome in lung cells of early RA patients and healthy smokers, finding that HLA-DR genotype drives the immunopeptidome more than RA status or sex.