Elie M. Adam

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors

This study shows how ketamine's effects on NMDA receptor kinetics lead to oscillatory brain dynamics observed in EEG and local field potential recordings.

Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model

This paper constructs a biophysical thalamocortical model to simulate propofol-induced EEG changes, revealing two dynamic states linked to cortical synchronization and brainstem influence.

Dynamic control of visually-guided locomotion through cortico-subthalamic projections

The paper investigates the role of cortico-subthalamic projections in controlling visually-guided locomotion in mice, finding that M2-STN pathway activity is critical for stopping behavior.

Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks

This study uses a biophysical model to show how deep brain stimulation (DBS) of the subthalamic nucleus can restore normal striatal rhythms in Parkinson's disease by modulating fast spiking interneurons and cortical noise.

Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior

This study identifies distinct roles of prefrontal cortex projections in modulating sensorimotor behavior through separate circuits for motor response coordination and sensory cue processing.