Nancy Kopell

Awake alpha bursting emerges as the dynamic working state in a lateral geniculate thalamocortical cell model

This paper introduces a computational model of a thalamocortical neuron that demonstrates how the awake alpha rhythm enables thalamic filtering of retinal signals and processing of non-sensory rhythms.

Basolateral amygdala oscillations enable fear learning in a biophysical model

This paper uses a biophysical model of the basolateral amygdala to show that specific interneurons generate rhythms critical for fear learning and plasticity.

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on the kinetics of NMDA receptors

This study shows how ketamine's effects on NMDA receptor kinetics lead to oscillatory brain dynamics observed in EEG and local field potential recordings.

Rapid thalamocortical network switching mediated by cortical synchronization underlies propofol-induced EEG signatures: a biophysical model

This paper constructs a biophysical thalamocortical model to simulate propofol-induced EEG changes, revealing two dynamic states linked to cortical synchronization and brainstem influence.

Interacting rhythms enhance sensitivity of target detection in a fronto-parietal computational model of visual attention

The paper develops a computational model of the fronto-parietal network to show how interacting rhythms enhance visual target detection sensitivity during sustained attention.

Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks

This study uses a biophysical model to show how deep brain stimulation (DBS) of the subthalamic nucleus can restore normal striatal rhythms in Parkinson's disease by modulating fast spiking interneurons and cortical noise.

Differential contributions of synaptic and intrinsic inhibitory currents to speech segmentation via flexible phase-locking in neural oscillators

The paper investigates how synaptic and intrinsic inhibitory currents contribute to flexible phase-locking in neural oscillators, enabling speech segmentation by identifying vocalic nuclei.

Layer and rhythm specificity for predictive routing

The paper investigates predictive coding in the brain by analyzing neural activity patterns in different cortical areas during a visual task, finding distinct frequency-specific routing mechanisms.

Prefrontal oscillations modulate the propagation of neuronal activity required for working memory

This study uses biophysically-detailed modeling to show that prefrontal cortex oscillations and local inhibition gate signal propagation from working memory, with resonant frequency tunable by deep layer excitability.

A biophysical model of striatal microcircuits suggests gamma and beta oscillations interleaved at delta/theta frequencies mediate periodicity in motor control

This paper proposes a biophysical model of striatal microcircuits showing how dopamine modulates gamma and beta oscillations interleaved at delta/theta frequencies to enable periodic motor control.

Flexible reset and entrainment of delta oscillations in primate primary auditory cortex: modeling and experiment

The paper shows how delta oscillations in primate auditory cortex are reset and entrained by auditory stimuli, using experimental data and a computational model.

Constraints on Persistent Activity in a Biologically Detailed Network Model of the Prefrontal Cortex with Heterogeneities

The paper shows that persistent activity in a prefrontal cortex model requires homogeneity in inhibitory neurons and synapses, which can be achieved through homeostatic plasticity.

Biased competition in the absence of input bias: predictions from corticostriatal computation

The paper presents a corticostriatal model showing how biased competition can occur without input bias through physiological asymmetries in striatal neurons.

Muscarinic receptors regulate auditory and prefrontal cortical communication during auditory processing

This study shows that muscarinic receptors in the auditory cortex regulate communication with the prefrontal cortex during passive auditory processing, influencing cortical gating and connectivity.

Flexible resonance in prefrontal networks with strong feedback inhibition

This paper shows that prefrontal cortex networks with strong feedback inhibition generate internal oscillations and selectively respond to external oscillations at similar frequencies, with resonance properties that can be tuned.

Striatal cholinergic receptor activation causes a rapid, selective, & state-dependent rise in corticostriatal β activity.

This study shows that activating striatal cholinergic receptors increases beta oscillations in the corticostriatal loop, with directional connectivity and subband-specific effects.