A Massively Parallel CRISPR-Based Screening Platform for Modifiers of Neuronal Activity
Steven C. Boggess, Vaidehi Gandhi, Ming‐Chi Tsai, Emily Marzette, Noam Teyssier, Joanna Yu-Ying Chou, Xiaoyu Hu, Amber L. Cramer, Lin Yadanar, Kunal Shroff, Claire G. Jeong, Céline Eidenschenk, Jesse E. Hanson, Ruilin Tian, Martin Kampmann
The paper develops a CRISPRi-based screening platform to identify genes affecting neuronal excitability in human iPSC-derived neurons, revealing new links to neurodegenerative and neurodevelopmental disorders.
bioRxiv · Feb 28, 2024 · PreprintNeuroscience