Meike Bartels

Epigenome-wide association study meta-analysis of wellbeing

This study conducts an epigenome-wide association study (EWAS) meta-analysis of wellbeing using DNA methylation data, finding no significant methylation sites but suggesting the need for larger studies.

The multidimensional structure of wellbeing: genetic evidence from a multivariate twin study including the Mental Health Continuum

This study uses multivariate twin analysis to show that wellbeing has distinct genetic components across its subscales and moderate to high genetic overlap with other wellbeing measures, but no single common genetic factor.

Major depression and atherosclerotic disease: Linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques

This study identifies shared genetic risk between major depression and atherosclerotic diseases and links causal gene expression changes in blood, brain, and heart tissues to depression etiology.

The Hidden Biology of Wellbeing: A Multi-Omics Analysis Across Genomic, Epigenomic, and Transcriptomic Layers.

This study uses multi-omics data from 2,320 participants to identify latent factors capturing shared variation across genomic, epigenomic, and transcriptomic layers, finding one factor associated with wellbeing, though its significance diminishes after covariate correction.

Intergenerational transmission of complex traits and the offspring methylome

The paper investigates how parental polygenic scores for complex traits are associated with offspring DNA methylation, finding significant links for schizophrenia, educational attainment, BMI, and height.

The association between metabolite concentrations and wellbeing in adults

This study investigates the link between blood metabolites and wellbeing in adults using a large sample from the Netherlands Twin Register, finding no significant associations but suggesting a potential role for lipid metabolism.

Genome-wide association meta-analysis of age at onset of walking

This paper conducts a genome-wide association meta-analysis of age at onset of walking, identifying 11 loci and showing genetic correlations with ADHD, BMI, intelligence, and brain structure.

Genome-wide analyses of vocabulary size in infancy and toddlerhood: associations with Attention-Deficit/Hyperactivity Disorder and cognition-related traits

This study identifies genetic links between early vocabulary development and ADHD and cognition traits using genome-wide analyses.

Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder

This study integrates genomics, epigenomics, and metabolomics data to identify ADHD biomarkers and explore omics-level connections, finding associations between PGSs, CpGs, and metabolites.

Distinguishing Happiness and Meaning in Life from Depressive Symptoms: a GWAS-by-subtraction study in the UK Biobank

This study uses GWAS-by-subtraction to identify genetic variants specific to happiness and meaning in life independent of depressive symptoms in the UK Biobank.

Ultra-rare and common genetic variant analysis converge to implicate negative selection and neuronal processes in the aetiology of schizophrenia

This study integrates GWAS and exome data with single-cell gene expression to show common and ultra-rare schizophrenia variants are enriched in brain-expressed, selection-sensitive genes.

Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children

This study examines heritability of urinary metabolites in children, finding substantial genetic contributions across amines, organic acids, and steroids.

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

The paper uses symptom-based case predictions to conduct a GWAS on COVID-19, finding new genetic susceptibility insights and suggesting different genetic architectures for severity and susceptibility.

Genetic evidence for a large overlap and potential bidirectional causal effects resilience and well-being.

This study investigates the genetic and environmental overlap and bidirectional causality between resilience and well-being using twin-sibling data and polygenic scores.

Within-sibship GWAS improve estimates of direct genetic effects

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

The genomic architecture of blood metabolites based on a decade of genome-wide analyses

This study estimates heritability and genetic contributions to metabolite levels using genome-wide data and twin-family cohorts, revealing class-specific genetic influences.

A genetic perspective on the relationship between eudaimonic -and hedonic well-being

The paper uses GWAS to investigate the genetic relationship between eudaimonic and hedonic well-being, finding high genetic correlation and shared biological pathways.

Stratified Linkage Disequilibrium Score Regression reveals enrichment of eQTL effects on complex traits is not tissue specific

The paper uses SLDSR to show that eQTL effects on complex traits are not tissue-specific, supporting the use of accessible tissues like blood for eQTL discovery.

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

This study identifies 4 new risk loci for cannabis use through GWAS, finds genetic overlap with mental health, and shows a causal link between schizophrenia and cannabis use.

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

This study identifies maternal genetic variants associated with offspring birth weight using GWAS and SEM, showing independent effects from fetal genetics.

Multivariate Genome-wide and integrated transcriptome and epigenome-wide analyses of the Well-being spectrum.

The paper identifies 63 genetic signals associated with well-being traits using genome-wide analyses and links them to gene expression and methylation in brain tissues.

Genetic Associations with Subjective Well-Being Also Implicate Depression and Neuroticism

The paper identifies genetic variants associated with subjective well-being, depressive symptoms, and neuroticism using genome-wide association studies and proxy-phenotype analyses.