This paper describes a tissue multiplexing method to increase spatial transcriptomics output from limited pathology specimens by combining multiple tissues on a single capture array.

Frontiers in Medicine · Apr 9, 2026Peer-reviewedGenetic & Genomic Medicine

Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in three Skin Cancer Types

P. Prakrithi, Laura F. Grice, Feng Zhang, Levi Hockey, Samuel X. Tan, Xiao Tan, Zherui Xiong, Onkar Mulay, Andrew Causer, Andrew Newman, Duy Pham, Guiyan Ni, Zewen Kelvin Tuong, Xinnan Jin, Eun Ju Kim, , Quan Hoang Nguyen

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.

bioRxiv · Jul 25, 2025 · PreprintCancer Biology

BMP-dependent oligoclonal cancer attractor state precedes neural crest fate in melanoma initiation

Alicia M. McConnell, Maggie H. Chassé, Haley R. Noonan, Jeffrey K. Mito, Julia Barbano, Erika Weiskopf, Irene F. Gosselink, Song P. Yang, Kyle D. Drake, Chloé S. Baron, Elise Layne, Meera Prasad, Phammela Abarzua, Maxime Grimont, Yung-Ching Kao, , Leonard Ira Zon

The paper identifies a BMP-dependent attractor state in melanoma precursor cells that precedes neural crest fate and is associated with ID1 expression in human melanoma.

bioRxiv · Oct 22, 2024 · PreprintCancer Biology