Srinidhi Rao Sripathy

This paper introduces automated high-throughput patch clamp electrophysiology methods for hiPSC-derived neurons, enabling efficient analysis of voltage-gated sodium channels and pharmacological responses.

The paper analyzes transcriptomic and proteomic data from specific brain regions to identify molecular changes in schizophrenia, showing superior regional discrimination in transcriptomic and proteomic data.

This study shows TCF4 mutations impair synaptic function in patient-derived cortical neurons by disrupting RIMBP2 expression, leading to deficits in synaptic transmission and network excitability.

CaPTure is a scalable pipeline for analyzing calcium imaging data from cultured neurons, enabling high-throughput phenotypic discovery.

The paper evaluates Nav1.8 as a therapeutic target for Pitt Hopkins Syndrome by reviewing literature and presenting data showing its inhibition normalizes neuron function and behavior in mouse models.

The paper identifies electrophysiological measures in hiPSC-derived neurons linked to schizophrenia diagnosis and cognitive performance.