Christopher Borcuk

Liquidity of gene co-expression trajectories across the lifespan highlights delayed maturation and the perinatal GABA switch in schizophrenia risk

The paper uses a novel 'liquidity' metric to analyze gene expression trajectories across lifespan, revealing delayed maturation and perinatal GABA switch in schizophrenia risk without detectable neuropathology.

Co-expression-based models improve eQTL predictions and highlightnovel transcriptome-wide genes associated with schizophrenia

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

Transcriptomics and proteomics of projection neurons in a circuit linking hippocampus with dorsolateral prefrontal cortex in the human brain

The paper analyzes transcriptomic and proteomic data from specific brain regions to identify molecular changes in schizophrenia, showing superior regional discrimination in transcriptomic and proteomic data.

A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing

The paper links miR-137 and its target genes to schizophrenia risk through emotion processing in the prefrontal cortex, showing allele associations with brain activation patterns.

Early memory deficits and extensive brain network disorganization in the AppNL-F/MAPT double knock-in mouse model of familial Alzheimer's disease.

This study uses an AD mouse model to show early memory deficits and brain network disorganization linked to specific neuropathology.