Lana M. Sheta

Evolution of the open-access CIViC knowledgebase is driven by the needsof the cancer variant interpretation community

The paper describes the evolution of the CIViC knowledgebase to meet the needs of the cancer variant interpretation community by expanding its functionality and data types.

The CIViC knowledge model and standard operating procedures for curation and clinical interpretation of variants in cancer

The paper describes the CIViC knowledge model and curation procedures for systematically organizing and interpreting cancer-related genetic variants.

Identification of community-consensus clinically relevant variants and development of single molecule molecular inversion probes using the CIViC database

The paper designs single molecule molecular inversion probes targeting clinically relevant variants using the CIViC database, demonstrating high sensitivity and discovering missed variants in cancer samples.

Standard operating procedure for somatic variant refinement of tumor sequencing data

This paper establishes a standard operating procedure for manual refinement of somatic variants in tumor sequencing data to improve consistency and reproducibility.