Author

Yalan Sheng

Hong Kong Baptist UniversityORCID 0000-0002-2152-356XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:long-read sequencing· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Shan GaoiD· 2 shared Yifan LiuiD· 2 shared Aili JuiD· 1 shared Bei NaniD· 1 shared Bo PaniD· 1 shared Chun LiiD· 1 shared Fei Ye· 1 shared Fei YeiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBioinformatics

Shan GaoORCID

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3 papers

Recent·Most cited

SMAC: identifying DNA N6-methyladenine (6mA) at the single-molecule level using SMRT CCS data

Haicheng Li, Junhua Niu, Yalan Sheng, Yifan Liu, Shan Gao

SMAC detects DNA N6-methyladenine at the single-molecule level using SMRT CCS data, improving accuracy over existing methods.

Briefings in Bioinformatics · Mar 1, 2025Peer-reviewedBioinformatics

Comprehensive genome annotation of the model ciliate Tetrahymena thermophila by in-depth epigenetic and transcriptomic profiling

Fei Ye, Xiao Chen, Yuan Li, Aili Ju, Yalan Sheng, Lili Duan, Jiachen Zhang, Zhe Zhang, Khaled A. S. Al‐Rasheid, Naomi A. Stover, Shan Gao

This study improves gene annotation in Tetrahymena thermophila by integrating transcriptomic and epigenetic data, adding new genes and UTRs while identifying antisense transcripts.

Nucleic Acids Research · Nov 12, 2024Peer-reviewedBioinformatics

Semi-conservative transmission of DNA N6-adenine methylation in a unicellular eukaryote

Yalan Sheng, Yuanyuan Wang, Wentao Yang, Xue Qing David Wang, Jiuwei Lu, Bo Pan, Bei Nan, Yongqiang Liu, Fei Ye, Chun Li, Jikui Song, Yali Dou, Shan Gao, Yifan Liu

The paper demonstrates that DNA N6-adenine methylation (6mA) is transmitted semi-conservatively in Tetrahymena thermophila, with AMT1-dependent maintenance and AMT1-independent de novo methylation mechanisms.

Genome Research · May 1, 2024Peer-reviewedMolecular Biology