Marcella Birtele

This study identifies ZNF462 as an epigenetic repressor that controls opposing developmental tempos in human neural and cranial neural crest lineages by regulating lineage-specific enhancers.

This study develops a 3D microculture method to generate mature dopamine neurons from patient fibroblasts, which can be transplanted into a Parkinson's disease rat model to form functional neuron grafts.

This study shows SYNGAP1, an autism risk gene, is expressed in human cortical progenitors and its dysfunction disrupts neurogenesis and cortical lamination.

The paper was withdrawn due to lack of full author consent and is not intended for citation.

This study generates patient-derived induced dopaminergic neurons to show age-related autophagy impairments and alpha-synuclein accumulation in Parkinson's disease.

The paper evaluates TH-Cre knock-in cell lines for identifying and isolating stem cell-derived dopaminergic neurons in vitro and in vivo.

The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.

The paper uses scRNA-seq to analyze graft composition in a Parkinson’s disease cell therapy model, revealing differences between human stem cell-derived and fetal tissue grafts.