Yen‐Chung Chen

The paper shows that the same selector transcription factor can be regulated by different patterning axes through distinct enhancers in Drosophila neurogenesis, revealing a cis-regulatory mechanism for neuronal diversity.

The paper shows that single-locus chromatin memory in Drosophila medulla progenitors allows spatial identity to be faithfully executed or flexibly bypassed during neuronal fate specification.

The paper identifies cell-type-specific enhancers and regulatory codes for neuronal differentiation in Drosophila using single-cell RNA and ATAC sequencing.

The paper quantifies social interactions in ants to show how structured dueling behavior predicts reproductive hierarchy formation.

The paper identifies HCRG1, a peptide that suppresses juvenile hormone to enable reproductive and longevity changes in ants.

The paper shows calcium waves in Drosophila retinal support cells coordinate uniform tissue patterning through gap junction networks and size-dependent mechanical responses.

This study uses single-cell transcriptomics to compare doublesex-expressing neurons across Drosophila species, revealing conserved cell types and species-specific gene expression differences in sexual circuits.

The paper identifies spatial subdomains in the Drosophila medulla and links patterning mechanisms to terminal selector expression in neuronal types.

The paper shows that spatial patterning in the Drosophila visual system regulates the number of Distal medulla inhibitory interneurons through domain subdivision and morphogenetic signaling.

The paper presents an aging Drosophila cell atlas, identifies cell type-specific aging patterns, and shows ribosomal gene expression as a conserved aging predictor.

The paper uses scRNA-seq to generate cell-type-specific split-GAL4 reagents for Drosophila development, demonstrating their effectiveness in targeting known cell types and identifying novel ones.

Drosophila larval optic lobe single-cell RNA-seq and pseudotime analysis define a near-complete medulla neuroblast temporal transcription factor series, with Eyeless and Dichaete acting as regulatory hubs.

This study uses single-cell transcriptomics to identify novel motor neuron subtypes in mice, revealing subtype diversity that increases in land animals and continues to evolve in humans.

This study identifies lncRNAs from the Dlk1-Dio3 locus that maintain postmitotic motor neuron fate and subtype identity by regulating H3K27me3 and Hox gene expression.