Marco Tullio Rigoli

High resolution multi-scale profiling of embryonic germ cell-like cells derivation reveals pluripotent state transitions in humans

This paper establishes a defined feeder-free system to convert human PGC-like cells to pluripotent stem cells, tracking transcriptional and epigenomic transitions using multi-omic analysis.

A molecular cell atlas of endocrine signalling in human neural organoids

This paper creates a molecular atlas of endocrine signaling in human neural organoids by perturbing seven hormonal pathways and analyzing their effects on neurodevelopment.

Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolution

The paper develops and validates multiplexing strategies for brain organoids combined with single cell RNA-seq to study neurodevelopmental trajectories across multiple genetic lines.

7q11.23 CNV alters protein synthesis and REST-mediated neuronal intrinsic excitability

This study investigates how 7q11.23 CNVs affect protein synthesis and neuronal excitability in neurodevelopmental disorders using patient-derived neurons and multi-omics approaches.

Human cortical organoids expose a differential function of GSK3 on direct and indirect neurogenesis

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.