Davide Castaldi

Co-regulatory changes in Homo sapiens prefrontal cortex shape RNA-chromatin interactions

The paper maps RNA-chromatin interactions in human prefrontal cortex, revealing co-regulatory changes linked to brain evolution and disease pathways.

A molecular cell atlas of endocrine signalling in human neural organoids

This paper creates a molecular atlas of endocrine signaling in human neural organoids by perturbing seven hormonal pathways and analyzing their effects on neurodevelopment.

Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution

The paper longitudinally profiles cerebellar organoids, benchmarks them against fetal data, and models mutations linked to autism and human brain evolution.

YY1 mutations disrupt corticogenesis through a cell-type specific rewiring of cell-autonomous and non-cell-autonomous transcriptional programs

This study investigates how YY1 mutations disrupt corticogenesis by altering transcriptional networks in neural progenitors and neurons, with non-cell-autonomous effects on astrocytes.

Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolution

The paper develops and validates multiplexing strategies for brain organoids combined with single cell RNA-seq to study neurodevelopmental trajectories across multiple genetic lines.

KMT2D haploinsufficiency in Kabuki Syndrome disrupts neuronal function through transcriptional and chromatin rewiring independent of H3K4-monomethylation

This study investigates how KMT2D mutations in Kabuki Syndrome disrupt neuronal function through chromatin and transcriptional changes, independent of H3K4me1.