Matthew C. Good

Spatially ordered zygotic genome activation fulfills embryo quality control

The paper shows that properly patterned zygotic genome activation (ZGA) is required for normal development and that embryos have a quality control system to detect and respond to mispatterned ZGA.

Delivery of Peptide Coacervates to Form Stable Interaction Hubs In Cells

The paper develops peptide-based compartments that can be delivered into cells to sequester targets and degrade them, demonstrating potential for synthetic organelles in cell engineering.

53BP1 condensates function as bioreactors for NHEJ directed DNA repair and insulators to determine pathway choice

This study shows 53BP1 condensates drive NHEJ foci formation and function as bioreactors and insulators to enhance DNA repair and pathway selection.

Assembly of Hierarchical Multiphase Condensates Using Designer Surfactant Proteins

This study engineers designer surfactant proteins to enable hierarchical assembly of immiscible biomolecular condensates, revealing strategies for spatial partitioning in synthetic materials.

A C. elegans Zona Pellucida domain protein functions via its ZPc domain

This study shows that the ZPc domain of LET-653 in C. elegans is primarily responsible for aECM assembly and tissue shaping, contradicting current models that emphasize the ZPn domain.