ImmunologybioRxivPreprint
Local glycan engineering induces systemic antitumor immune reactions via antigen cross-presentation
Natália Rodrigues Mantuano, Michael T. Sandholzer, Emiel Rossing…·Heinz Philipp Laubli
This study shows that local glycan engineering using AAV-delivered sialidases reduces tumor growth and enhances systemic antitumor immunity through improved cross-presentation and dendritic cell activation.
DOI 10.64898/2026.05.04.720097