Author

Natália Rodrigues Mantuano

University of BaselORCID 0000-0002-1302-7013Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Andreas ZinggiD· 3 shared Heinz Philipp LaubliiD· 3 shared Alfred ZippeliusiD· 2 shared Andreas HolbroiD· 2 shared Helen ThutiD· 2 shared Mascha BinderiD· 2 shared Matthias Sebastian MatteriD· 2 shared Michael T. SandholzeriD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Andreas ZinggORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Local glycan engineering induces systemic antitumor immune reactions via antigen cross-presentation

Natália Rodrigues Mantuano, Michael T. Sandholzer, Emiel Rossing, Johan F. A. Pijnenborg, Andreas Zingg, Filip Filipsky, Ronja Wieboldt, Amanda Carlos Paulino, Isabelle V. M. Siqueira, Thomas Jan Boltje, Heinz Philipp Laubli

This study shows that local glycan engineering using AAV-delivered sialidases reduces tumor growth and enhances systemic antitumor immunity through improved cross-presentation and dendritic cell activation.

bioRxiv · May 7, 2026 · PreprintImmunology

Longitudinal profiling of tumor-reactive T cells during TIL therapy in metastatic melanoma

Michael T. Sandholzer, Clara Serger, Alessia G Liner, Sarp Uzun, David König, Helen Thut, Reto Ritschard, Jonas D. Fürst, Andreas Zingg, Natália Rodrigues Mantuano, Benjamin Kasenda, Katharina Glatz, Elisabeth A. Kappos, Matthias Sebastian Matter, Andreas Holbro, , Heinz Philipp Laubli

This study profiles tumor-reactive T cell dynamics during TIL therapy in metastatic melanoma, identifying factors associated with response and resistance.

bioRxiv · Sep 23, 2025 · PreprintImmunology

Targeting cancer-associated glycosylation for adoptive T cell therapy of gastro-intestinal and gynecological cancers

Andreas Zingg, Reto Ritschard, Helen Thut, Mélanie Buchi, Andreas Holbro, Anton Oseledchyk, Viola A Heinzelmann-Schwarz, Andreas S. Buser, Mascha Binder, Alfred Zippelius, Natália Rodrigues Mantuano, Matthias Sebastian Matter, Heinz Philipp Laubli

This study develops a fully human CAR-T cell therapy targeting the STn antigen, showing activity in preclinical models of gastro-intestinal and gynecological cancers.

Cancer Immunology Research · Apr 16, 2025Peer-reviewedCancer Biology