Microbial GenomicsGenomicsPeer-reviewed journal article
Identification of a Chimeric M4 Protein and Novel Emm Pattern in Currently Circulating Strains of Emm4 Group A Streptococcus
Sruti DebRoyiD, Xiqi LiiD, Awdhesh KaliaiD, Jessica Galloway-PeñaiD, Brittany J. Shah, Vance G. FowleriD, Anthony R. FloresiD, Samuel A. ShelburneiD
Abstract
Group A Streptococcus (GAS) is classified by sequence of the gene encoding the M protein (emm) and the patterns into which emm types are grouped. We discovered a novel emm pattern in emm4 GAS, historically considered pattern E, arising from a fusion event between emm and the adjacent enn gene. We identified the emm/enn fusion event in 51/52 emm4 GAS strains isolated by national surveillance in 2015. GAS isolates with an emm/enn fusion event completely replaced pattern E emm4 strains over a 4-year span in Houston (2013-2017). The novel emm/enn gene fusion and new emm pattern has potential vaccine implications.
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- top 14%
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