Author

Xiaodong Zhu

Icahn School of Medicine at Mount SinaiORCID 0000-0002-6432-8385Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Michelle E. EhrlichiD· 2 shared Sam GandyiD· 2 shared Aisha Al-subaie· 1 shared Allen L. PaniD· 1 shared Bin ZhangiD· 1 shared Emmy Sakakibara· 1 shared Eric E. SchadtiD· 1 shared Ilya KruglikoviD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Michelle E. EhrlichORCID

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2 papers

Recent·Most cited

miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer's disease

Xiaodong Zhu, Jean‐Vianney Haure‐Mirande, Mesude Bicak, Pengfei Dong, Ilya Kruglikov, Aisha Al-subaie, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich

The paper investigates miR155's role in hippocampal GABAergic neurogenesis in Alzheimer's disease, finding it regulates NSC dynamics and interneuron development with opposing effects compared to microglial miR155.

bioRxiv · Sep 28, 2025 · PreprintNeuroscience

Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice

Allen L. Pan, Mickaël Audrain, Emmy Sakakibara, Rajeev Joshi, Xiaodong Zhu, Qian Wang, Minghui Wang, Noam D. Beckmann, Eric E. Schadt, Sam Gandy, Bin Zhang, Michelle E. Ehrlich, Stephen R. Salton

This study shows that DUSP6 overexpression in the dorsal hippocampus of male 5xFAD mice reduces amyloid load and improves memory, while also reducing neuroinflammation in both sexes.

Frontiers in Aging Neuroscience · Jun 28, 2024Peer-reviewedNeuroscience