Scott Noggle

Genetics of growth rate in induced pluripotent stem cells

The paper identifies genetic factors influencing iPSC growth rates, finding rare variants in WDR54 and a polygenic background explaining most variance.

miR155 triplicated in Down syndrome regulates hippocampal GABAergic neurogenesis in Alzheimer's disease

The paper investigates miR155's role in hippocampal GABAergic neurogenesis in Alzheimer's disease, finding it regulates NSC dynamics and interneuron development with opposing effects compared to microglial miR155.

Common genetic variation impacts molecular stress response in the brain

The paper identifies stress-interactive eQTLs that dysregulate gene expression in the brain under stress, uncovering novel genes linked to brain disorder risk in traumatic stress contexts.

Studies on the International Space Station to assess the effects of microgravity on iPSC-derived neural organoids

This study examines the effects of microgravity on iPSC-derived neural organoids using samples from the International Space Station, finding reduced cell proliferation and increased neural maturity in space-cultured organoids.

Reprogramming method does not impact the neuronal differentiation potential of 16p11.2 deletion patient iPSCs

The study compares reprogramming methods for 16p11.2 deletion patient iPSCs and finds no significant differences in their differentiation potential into functional neurons.

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human induced pluripotent stem cells, neural stem cells and neurons

The paper examines how ER/mitochondrial coupling changes during human neuronal development and links it to Alzheimer's disease pathology.