Valentina Fossati

The paper shows that IFNγ and proinflammatory cytokines activate astrocytes to express antigen-presenting machinery, supporting CD4+ T cell restimulation in vitro and in vivo.

The paper generates and characterizes a custom genome assembly for the KOLF2.1J iPSC line to improve genomic analysis accuracy compared to standard references.

The paper investigates miR155's role in hippocampal GABAergic neurogenesis in Alzheimer's disease, finding it regulates NSC dynamics and interneuron development with opposing effects compared to microglial miR155.

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

The paper uses iPSC-derived glia cultures from MS patients to identify glia-intrinsic disease mechanisms and potential therapeutic targets.

This study examines the effects of microgravity on iPSC-derived neural organoids using samples from the International Space Station, finding reduced cell proliferation and increased neural maturity in space-cultured organoids.

The paper uses scRNAseq data from mouse and human to identify candidate genes for glial fate specification and optimize astrocyte differentiation protocols.

This study identifies CD49f as a marker to isolate functional human iPSC-derived astrocytes, which can be stimulated to exhibit a neurotoxic phenotype relevant to neurodegenerative diseases.