This paper develops a dual-hit mouse model of schizophrenia combining maternal immune activation and postnatal THC exposure, finding reduced Reelin levels and altered brain structure in treated mice.

Translational Psychiatry · Jul 16, 2026Peer-reviewedNeuroscience

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

Raquel A. Martínez García de la Torre, Júlia Vallverdú, Zhixin Xu, Sílvia Ariño, Raquel Ferrer‐Lorente, Laura Zanatto, María Mercado-Gómez, Beatriz Aguilar‐Bravo, Paloma Ruiz-Blázquez, M. Guadalupe Fernández, Artur Navarro‐Gascon, Albert Blasco‐Roset, Paula Sànchez‐Fernàndez‐de‐Landa, Joan Pera, Damià Romero–Moya, , Pau Sancho‐Bru

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

Nature Communications · Feb 10, 2025Peer-reviewedCell Biology

The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

Florent Sauvé, Sreekala S. Nampoothiri, Sophie A. Clarke, Daniela Fernandois, Caio Fernando Ferreira Coêlho, Julie Dewisme, Edouard Mills, Gaëtan Ternier, Ludovica Cotellessa, Cristina Iglesias, Helge Müller‐Fielitz, Thibaud Lebouvier, Romain Perbet, V. Florent, Marc Baroncini, , Vincent Prévot

The paper investigates SARS-CoV-2 infection in the hypothalamus and associated regions, showing viral entry receptors and susceptibility factors linked to neurological symptoms in COVID-19.

EBioMedicine · Sep 13, 2023Peer-reviewedNeuroscience

ChemPert: mapping between chemical perturbation and transcriptional response for non-cancer cells

Menglin Zheng, Satoshi Okawa, Miren Bravo, Fei Chen, Maria Luz Martínez‐Chantar, Antonio del Sol

ChemPert provides a database of transcriptional responses in non-cancer cells to improve drug response predictions for non-cancer diseases.

Nucleic Acids Research · Sep 25, 2022Peer-reviewedBioinformatics