This study investigates how diabetic conditions alter the 3D chromatin architecture and epigenome of macrophages, revealing disease-associated rewiring of the 3D epigenome and potential therapeutic targets.

bioRxiv · Oct 8, 2026 · PreprintGenomics

Long-Term Impact of Cumulative Hyperglycaemia on DNA Methylation and its Role in Diabetic Kidney Disease

Xiaoqi Luo, Anna Syreeni, Claire Hill, Laura Jane Smyth, Emma H. Dahlström, Stefan Mutter, Zhuo Chen, Rama D Natarajan, Siyu Pan, Andrew Parton, Heather Jackson, Gareth J. McKay, Katalin Suszták, Joel N. Hirschhorn, José C. Florez, , Niina Sandholm

The paper identifies DNA methylation changes linked to cumulative hyperglycaemia in type 1 diabetes and links some to diabetic kidney disease through Mendelian randomization.

medRxiv · Sep 3, 2026 · PreprintGenetic & Genomic Medicine

Blood methylation biomarkers are associated with diabetic kidney disease progression in type 1 diabetes

Anna Syreeni, Emma H. Dahlström, Laura Jane Smyth, Claire Hill, Stefan Mutter, Yogesh Gupta, Valma Harjutsalo, Zhuo Chen, Rama D Natarajan, Andrzej S. Królewski, Joel N. Hirschhorn, José C. Florez, Alexander Peter Maxwell, Per‐Henrik Groop, Amy Jayne McKnight, Niina Sandholm

The paper identifies DNA methylation biomarkers associated with diabetic kidney disease progression in type 1 diabetes using a prospective cohort study.

medRxiv · Nov 28, 2024 · PreprintGenetic & Genomic Medicine

Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanisms

Nayi Wang, Ji Zheng, Zhuo Chen, Liu Yang, Burak Dura, Minsuk Kwak, Juliana M. Xavier-Ferrucio, Yi-Chien Lu, Miaomiao Zhang, Christine Roden, Jijun Cheng, Diane S. Krause, Ye Ding, Rong Fan, Jun Lü

The paper co-sequences microRNAs and mRNAs in single cells to show miRNA variability contributes to non-genetic cell-to-cell heterogeneity and identifies new regulatory relationships.

bioRxiv · Sep 30, 2018 · PreprintSystems Biology