Author

Marcel L. Verdonk

Astex PharmaceuticalsORCID 0000-0002-6484-3328Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:CRISPR screen· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein sequence· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Thomas G. DaviesiD· 2 shared Alex Watterson· 1 shared Barbara Abreu· 1 shared Benoît BaillifiD· 1 shared Cansu DinçeriD· 1 shared Carl R. PoelkingiD· 1 shared Emre KarakoçiD· 1 shared Gabriele PiccoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Thomas G. DaviesORCID

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2 papers

Recent·Most cited

Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells

Katrina McCarten, Barbara Abreu, Benoît Baillif, Lisa Koob, Jong Sook Ahn, Cansu Dinçer, Julian Esselborn, Emre Karakoç, R. Frederick Ludlow, John F. Lyons, Gabriele Picco, Mamta Sharma, Marcel L. Verdonk, Mark R. Wade, Samantha J. Walker, , Mathew J. Garnett

The paper uses CRISPR base editing and structural analysis to identify functional residues in the PI3K pathway, revealing potential drug targets and allosteric pockets.

bioRxiv · Sep 14, 2026 · PreprintGenomics

Mapping the space of protein binding sites with sequence-based protein language models

Tuğçe Oruç, Maria Kadukova, Thomas G. Davies, Marcel L. Verdonk, Carl R. Poelking

The paper develops a method combining protein language models with 3D tesselation to create detailed binding site representations, improving downstream tasks like druggability modeling and benchmarking.

Bioinformatics · Jun 1, 2025Peer-reviewedBiochemistry