Author

Julian Esselborn

ORCID 0000-0002-3499-8417Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Alex Watterson· 1 shared Anita AdamiiD· 1 shared Anna I. WernickiD· 1 shared Annelies QuaegebeuriD· 1 shared Antonina KouliiD· 1 shared Barbara Abreu· 1 shared Benoît BaillifiD· 1 shared Cansu DinçeriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Alex Watterson

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2 papers

Recent·Most cited

Structure-function analysis of PI3K signalling cascade base editing screens in cancer cells

Katrina McCarten, Barbara Abreu, Benoît Baillif, Lisa Koob, Jong Sook Ahn, Cansu Dinçer, Julian Esselborn, Emre Karakoç, R. Frederick Ludlow, John F. Lyons, Gabriele Picco, Mamta Sharma, Marcel L. Verdonk, Mark R. Wade, Samantha J. Walker, , Mathew J. Garnett

The paper uses CRISPR base editing and structural analysis to identify functional residues in the PI3K pathway, revealing potential drug targets and allosteric pockets.

bioRxiv · Sep 14, 2026 · PreprintGenomics

The annotation and function of the Parkinson's and Gaucher disease-linked gene GBA1 has been concealed by its protein-coding pseudogene GBAP1

Emil Karl Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina Hertfelder Reynolds, James R. Evans, Zhongbo Chen, Melissa Grant‐Peters, Hannah L. Macpherson, Kylie Montgomery, Rhys Dore, Anna I. Wernick, , Mina Ryten

The paper shows that sequencing ambiguity between GBA1 and its pseudogene GBAP1 affects transcriptomic analysis, revealing non-lysosomal functions in the brain and widespread annotation inaccuracies.

Science Advances · Jun 26, 2024Peer-reviewedGenetics