S1PR1 Regulates Lymphatic Valve Development And Prevents Ileitis-Independent Tertiary Lymphoid Organ Formation
Xin Geng, Lijuan Chen, Zoheb Ahmed, Guilherme Pedron Formigari, Yen‐Chun Ho, Ilaria Del Gaudio, Marcella Neves Dátilo, Zheila J. Azartash-Namin, Xindi Shan, Ravi Shankar Keshari, Hong Chen, Florea Lupu, Lijun Xia, Gwendalyn J. Randolph, Scott D. Zawieja, , R. Sathish Srinivasan
This study shows that S1PR1 regulates lymphatic valve development and prevents tertiary lymphoid organ formation in the terminal ileum, suggesting TLOs as a sign of subclinical inflammation.
bioRxiv · Sep 30, 2024 · PreprintDevelopmental Biology