Author

Huayu Sun

University of VirginiaORCID 0000-0002-6532-7018Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

Jaideep KapuriD· 2 shared Aiying ZhangiD· 1 shared Alev ErişiriD· 1 shared Allison Tucker· 1 shared Angelina S. JuneiD· 1 shared Ankarao KalluriiD· 1 shared Challa Vijaya KumariD· 1 shared Chengsan SuniD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Jaideep KapurORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Modeling Alzheimer's Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic Targets

Eliana Sherman, Kevin Qiu, Rebecca Roberts, Lucille Shichman, Sihan Li, Huayu Sun, Lucie Ide, Allison Tucker, Seonjoo Lee, Weronika Gniadzik, Jung Bum Shin, Katia Sol‐Church, Jaideep Kapur, Aiying Zhang, Alev Erişir, , the Alzheimer’s Disease Neuroimaging Initiative

The paper develops a 3D brain assembloid model to study Alzheimer's disease progression and identifies IGFBP pathways as therapeutic targets in APOE4 carriers.

bioRxiv · Oct 17, 2025 · PreprintNeuroscience

Lactate receptor, HCAR1, in neonatal hypoxic-ischemic encephalopathy

Jennifer C. Burnsed, Angelina S. June, Maria Marlicz, Emmy Zucker, Ellie Kain-Kuzienski, Hannah Mulhern, Leanne Maharaj, Chengsan Sun, Suchitra Joshi, Huayu Sun, Jaideep Kapur

This study examines HCAR1 expression and function in neonatal brains, finding that HCAR1 modulates neuronal excitability and that its absence worsens hypoxic-ischemic seizures.

bioRxiv · Sep 16, 2025 · PreprintNeuroscience

Engineered dsRNA-protein nanoparticles for effective long-distance transport, delivery and gene silencing in plants

Huayu Sun, Ankarao Kalluri, Dan Tang, Jingwen Ding, Longmei Zhai, Xianbin Gu, Yanjun Li, Huseyin Yer, Xiaohan Yang, Gerald A. Tuskan, Zhanao Deng, Frederick G. Gmitter, Hui Duan, Challa Vijaya Kumar, Yi Li

This paper demonstrates the effective long-distance transport and gene silencing in plants using cationized bovine serum albumin (cBSA) bound to double-stranded RNA nanocomplexes.

bioRxiv · Oct 12, 2023 · PreprintMolecular Biology