Ryosuke Kojima

Biosensor-enabled single-molecule enzyme activity profiling for function-based molecular counting

This paper introduces a biosensor-based method for single-molecule enzyme activity profiling without enzyme-specific substrates, enabling absolute quantification of active enzyme molecules in cellular and circulating samples.

Enzyme activity as an actionable axis for small-molecule precision oncology

This paper develops enzyme activity-based prodrugs for precision oncology, showing reduced toxicity and improved efficacy in tumor models.

Low-Background Cancer Imaging With a Bioorthogonal Fluorescence Probe and Engineered Reporter Enzyme Bearing a Targeting Moiety

The paper develops a bioorthogonal fluorescence probe and engineered enzyme for low-background cancer imaging in mouse models.

The glomerulus as a selective gate for tumor-derived extracellular vesicles in urine

This study shows the glomerulus actively transports tumor-derived extracellular vesicles into urine, revealing a mechanism for their excretion and potential use in cancer diagnostics.