José C. Casas-Martinez

Peroxiredoxin 6 limits mitochondrial peroxidation to prevent mitochondrial ER contact site assembly and inflammatory signalling following adaptive stress

This study shows PRDX6 limits mitochondrial lipid peroxidation under oxidative stress, preventing MERCS formation and inflammation in both myoblasts and C. elegans.

Mitochondrial redox homeostasis links organellar stress surveillance to germline and somatic integrity in Caenorhabditis elegans

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

PERK orchestrates MERCS formation and mitochondrial remodelling promoting physiological adaptations during adaptive UPR signalling

This study shows PERK promotes MERCS formation and mitochondrial remodelling during adaptive UPR signalling in myoblasts and C. elegans, enhancing physiological function.

Exercise Related microRNAs in C. elegans Regulate Calcium Homeostasis and Mitochondrial Dynamics: Conserved pathways, Divergent mircoRNAs

This study identifies exercise-related microRNAs in C. elegans that regulate calcium homeostasis and mitochondrial dynamics, showing conserved pathways but divergent microRNAs across species.

Peroxiredoxin 2 Regulates DAF-16/FOXO Mediated Mitochondrial Remodelling in Response to Exercise that is Disrupted in Ageing

This study shows PRDX-2 regulates DAF-16/FOXO-mediated mitochondrial remodelling during exercise, which is disrupted in ageing in C. elegans.

Peroxiredoxin 2 is required for the redox mediated adaptation to exercise

The paper shows that Peroxiredoxin 2 is essential for the beneficial adaptive response to exercise-induced oxidative stress in C. elegans.