Brian McDonagh

This study shows that PRDX6's iPLA2 activity protects hepatocarcinoma cells from ferroptosis by maintaining lipid homeostasis and mitophagy.

This study shows PRDX6 limits mitochondrial lipid peroxidation under oxidative stress, preventing MERCS formation and inflammation in both myoblasts and C. elegans.

This study shows that loss of mitochondrial glutathione reductase and thioredoxin reductase in C. elegans causes growth, fertility, and muscle defects, activates a constitutive UPRmt, and alters mitochondrial morphology.

This study shows PERK promotes MERCS formation and mitochondrial remodelling during adaptive UPR signalling in myoblasts and C. elegans, enhancing physiological function.

This study shows miR-1 regulates metabolic flexibility in skeletal muscle by controlling pyruvate metabolism, with loss of miR-1 causing metabolic inflexibility and reduced endurance.

This study identifies exercise-related microRNAs in C. elegans that regulate calcium homeostasis and mitochondrial dynamics, showing conserved pathways but divergent microRNAs across species.

This study identifies miR-379-3p as a regulator of cancer cachexia by modulating purinergic receptors, mitochondrial function, and inflammatory responses in a sex-dependent manner.

This study shows PRDX-2 regulates DAF-16/FOXO-mediated mitochondrial remodelling during exercise, which is disrupted in ageing in C. elegans.

The paper shows that Peroxiredoxin 2 is essential for the beneficial adaptive response to exercise-induced oxidative stress in C. elegans.