Author

Lucas Tafur

Heidelberg UniversityORCID 0000-0002-6618-9649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Caroline Gabus· 2 shared Robbie LoewithiD· 2 shared Ariane Bergmann· 1 shared Christoph W. MülleriD· 1 shared Félix WeisiD· 1 shared Jonas HanskeiD· 1 shared Lenny BonadeiiD· 1 shared Luoming Zou· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

Caroline Gabus

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3 papers

Recent·Most cited

Structural basis for TORC2 activation

Luoming Zou, Maria G. Tettamanti, Caroline Gabus, Ariane Bergmann, Robbie Loewith, Lucas Tafur

This study determines the cryo-EM structure of yeast TORC2, revealing how phosphoinositides activate it through structural rearrangements involving regulatory subunits.

Molecular Cell · Apr 1, 2026Peer-reviewedBiochemistry

Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex

Lucas Tafur, Lenny Bonadei, Yiqiang Zheng, Caroline Gabus, Robbie Loewith

This study determines the cryo-EM structure of the SEAC-EGOC supercomplex in yeast and shows its role in amino acid signaling to TORC1, revealing how SEACIT and SEACAT regulate this process.

Nature Structural & Molecular Biology · Feb 12, 2026Peer-reviewedBiochemistry

Structural rearrangement of TFIIS- and TFIIF/TFIIE-like subunits in RNA polymerase I transcription complexes

Lucas Tafur, Yashar Sadian, Jonas Hanske, René Wetzel, Félix Weis, Christoph W. Müller

The paper presents cryo-EM structures of yeast Pol I elongation complexes bound to GMPCPP, revealing structural rearrangements involving TFIIE/TFIIF-like and TFIIS-like subunits.

eLife · Mar 26, 2019Peer-reviewedMolecular Biology