Robbie Loewith

The paper identifies atonosomes as tension-responsive plasma membrane-derived compartments in yeast, showing they form rapidly in response to membrane tension loss and are regulated by cell wall dynamics.

This study determines the cryo-EM structure of yeast TORC2, revealing how phosphoinositides activate it through structural rearrangements involving regulatory subunits.

This study determines the cryo-EM structure of the SEAC-EGOC supercomplex in yeast and shows its role in amino acid signaling to TORC1, revealing how SEACIT and SEACAT regulate this process.

The paper introduces in-cell LiP-MS to study protein structural changes and biomolecular condensates in live human cells, revealing structural alterations under stress and validating them with microscopy.

The paper shows that TORC2 regulates sterol redistribution to recover from membrane perturbation by small amphipathic molecules in yeast and mammalian cells.

The paper constructs a genome-scale genetic interaction network from 4 million double mutants in HAP1 cells, revealing conserved genetic network principles across species and uncovering novel gene functions and cancer dependencies.

The paper uses dynamic metabolomics to identify potential TOR signaling genes in yeast by analyzing metabolite responses to rapamycin treatment.

This study identifies Ddi1 as a protease involved in DNA-protein crosslink repair in yeast, showing its role in evicting crosslinked proteins from DNA.