Sheng Liu

scDenorm: a denormalisation tool for integrating single-cell transcriptomics data

scDenorm reverts normalized single-cell omics data to raw counts to improve integration and reduce biases in downstream analysis.

Kinetic principles underlying pioneer function of GAGA transcription factor in live cells

The paper studies the kinetic behavior of the GAGA transcription factor in live Drosophila cells, showing it stably binds chromatin for over 2 minutes, independent of chromatin remodelers.

Spatio-Temporal Coordination Of Transcription Preinitiation Complex Assembly In Live Cells

This study uses live-cell imaging in yeast to show how PIC components explore the nucleus and assemble at promoters, revealing spatio-temporal coordination in transcription initiation.

Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin

The paper uses single-molecule imaging to study chromatin remodelers in budding yeast, revealing their fast kinetics and ATP-dependent dissociation from chromatin.

Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

The paper uses live-cell single particle imaging to show that RNA polymerase II and Kin28/Cdk7 kinase are required for H2A.Z eviction in yeast, linking it to transcription processes.

Directed robust generation of functional retinal ganglion cells from Muller glia

This study reprograms mature mouse Muller glia into functional retinal ganglion cells using Math5 and Brn3 TFs, demonstrating efficient in vivo regeneration and therapeutic potential for glaucoma.

Neuronal thresholds and correlations in the peripheral vestibular system during rotation discrimination

This study measures neuronal and behavioral thresholds during rotation discrimination in macaques, finding similar thresholds and significant neuronal correlations but no trial-by-trial activity-behavior link.