Author

Alexandra K. Walker

University of Birmingham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Joanna R. MorrisiD· 4 shared Akhil BowryiD· 2 shared Alexander J. GarviniD· 2 shared Alexander J. Lanz· 2 shared Eva PetermanniD· 2 shared Richard D. KellyiD· 2 shared Aditi KanhereiD· 1 shared Aidan J. DohertyiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMolecular Biology

Joanna R. MorrisORCID

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4 papers

Recent·Most cited

The 7SK small nuclear ribonucleoprotein links the cell responses to transcription and replication stress by promoting replication fork reversal and homologous recombination

Akhil Bowry, Claire Wilson, Richard D. Kelly, Rosanna J. Wilkins, Alexandra K. Walker, Christy Susan Varghese, Zahraa A M Alshatti, Siobhan Murphy-Hollies, Joanna R. Morris, Sylvain Egloff, Aditi Kanhere, Eva Petermann

This study shows that 7SK-snRNP components HEXIM1 and LARP7 promote replication fork reversal and homologous recombination under transcription and replication stress, independent of BRCA1.

Nucleic Acids Research · Oct 24, 2026Peer-reviewedMolecular Biology

SUMO4 promotes SUMO deconjugation required for DNA double-strand break repair.

Alexander J. Garvin, Alexander J. Lanz, George E. Ronson, Matthew J.W. Mackintosh, Katarzyna Starowicz, Alexandra K. Walker, Yara Aghabi, Hannah L. Mackay, Ruth M. Densham, Jai S. Bhachoo, Aneika C. Leney, Joanna R. Morris

This study identifies SUMO4 as a critical regulator of DNA double-strand break repair by promoting SUMO deconjugation through SENP1 and preventing excessive SUMOylation.

Molecular Cell · Mar 1, 2025Peer-reviewedMolecular Biology

The SUMO activating enzyme subunit, SAE2, contributes SUMO protein bias for mitotic fidelity.

Alexandra K. Walker, Alexander J. Lanz, Mohammed Jamshad, Alexander J. Garvin, Peter J. Wotherspoon, Benjamin F Cooper, Timothy J. Knowles, Joanna R. Morris

This study shows that SAE2 deacetylation during mitosis biases SUMO2 over SUMO1 conjugation, affecting mitotic fidelity through SUMOylation of NuMA.

bioRxiv · Mar 18, 2022 · PreprintMolecular Biology

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Ann Liza Piberger, Akhil Bowry, Richard D. Kelly, Alexandra K. Walker, Daniel González‐Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann

This study shows that PrimPol creates single-stranded gaps at bulky DNA adducts, which recruit RAD51 for homologous recombination, facilitating DNA repair in mammalian cells.

Nature Communications · Nov 17, 2020Peer-reviewedMolecular Biology