Julian Hengsteler

A reinforcement learning framework for goal-directed stimulation of engineered neuronal networks

This paper introduces a reinforcement learning framework for controlling engineered neuronal networks to identify stimulation patterns that drive specific activity motifs.

HydroMEA: A 3D Hydrogel Based Microfluidic Device to Study Electrophysiology for Myelinated Nerve-on-Chip

The paper introduces hydroMEA, a 3D hydrogel-based microfluidic device that enables real-time electrophysiological measurements of myelinated nerve-on-chip systems using human iPSC-derived neurons and Schwann cells.

An implantable biohybrid nerve model towards synaptic deep brain stimulation

This paper develops an implantable biohybrid nerve model for synaptic deep brain stimulation, demonstrating in vitro and in vivo functionality for over 22 days.

A modular and flexible open source cell incubator system for mobile and stationary use

The paper introduces a modular and flexible open-source cell incubator system for both mobile and stationary use, enabling customized incubation for diverse experimental needs.

Conformational Dynamics in Aptamer Modulate Neurotransmitter Sensing in Nanopores

This study examines how conformational changes in aptamers affect neurotransmitter sensing in nanopores, showing opposite electronic responses to dopamine and serotonin.

Theoretical Analysis of Divalent Cation Effects on Aptamer Recognition of Neurotransmitter Targets

This study uses molecular dynamics simulations to analyze how divalent cations affect aptamer conformational changes when binding neurotransmitters like dopamine and serotonin.

Nanoscale patterning of in vitro neuronal circuits

This paper develops a method to pattern neuronal circuits in vitro using nanoscale structures to guide synapse formation between isolated neuron groups.

Engineered biological neural networks on high density CMOS micro electrode arrays

This paper describes a method to engineer biological neural networks on high-density CMOS microelectrode arrays to improve spatial resolution and axon guidance.