Molecular BiologyNature CommunicationsPeer-reviewed
Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase
Huawei Tong, Haoqiang Wang, Xuchen Wang…·Hui Yang
This paper develops two deaminase-free base editors, gTBE and gCBE, for direct T and C editing using engineered UNG variants, achieving high editing efficiencies in human cells.
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