Fan Guo

Causality-oriented regulatory inference and rational transcriptomic reprogramming design with CASCADE

CASCADE is a framework for causal regulatory inference and rational transcriptomic reprogramming design, enabling causal discovery and intervention design for targeted cells.

The longitudinal single-cell panorama of cynomolgus monkey ovary throughout lifespan revealed a conserved ovarian clock between primates

The paper constructs a longitudinal single-cell atlas of cynomolgus monkey ovaries across 22 years, identifies a novel oocyte type, and develops a transcriptomic ovarian clock applicable to humans.

Interspecies blastocyst complementation generates functional rat cell-derived forebrain tissues in mice

This study uses interspecies blastocyst complementation to generate functional rat-derived forebrain tissues in mice, revealing developmental and xenogeneic barriers.