Xiali Yang

This study uses interspecies blastocyst complementation to generate functional rat-derived forebrain tissues in mice, revealing developmental and xenogeneic barriers.

The paper designs high-fidelity Cas13 variants with minimal collateral RNA degradation effects, validated in mammalian cells and transgenic mice.

This study demonstrates the use of CasRx-mediated RNA knockdown to modulate metabolic genes in mouse liver, showing efficient and reversible reduction of PCSK9 and cholesterol levels.