Author

Bingbing He

Chinese Academy of SciencesORCID 0000-0002-9790-8087Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:rat· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Hui YangiD· 4 shared Wenqin YingiD· 3 shared Xiali YangiD· 3 shared Yingsi ZhouiD· 3 shared Chunlong XuiD· 2 shared Jia HuangiD· 2 shared Jing LiuiD· 2 shared Mingxing Xue· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersGenomics

Hui YangORCID

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4 papers

Recent·Most cited

Interspecies blastocyst complementation generates functional rat cell-derived forebrain tissues in mice

Jia Huang, Bingbing He, Xiali Yang, Xin Long, Yinghui Wei, Yanxia Gao, Yuan Fang, Wenqin Ying, Zikang Wang, Chao Li, Yingsi Zhou, Shuaishuai Li, Linyu Shi, Fan Guo, Haibo Zhou, , Jun Wu

This study uses interspecies blastocyst complementation to generate functional rat-derived forebrain tissues in mice, revealing developmental and xenogeneic barriers.

bioRxiv · Apr 13, 2023 · PreprintDevelopmental Biology

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effect

Huawei Tong, Jia Huang, Qingquan Xiao, Bingbing He, Xue Dong, Yuanhua Liu, Xiali Yang, Dingyi Han, Zikang Wang, Xuchen Wang, Wenqin Ying, Runze Zhang, Wei Yu, Chunlong Xu, Yingsi Zhou, , Hui Yang

The paper designs high-fidelity Cas13 variants with minimal collateral RNA degradation effects, validated in mammalian cells and transgenic mice.

Nature Biotechnology · Aug 11, 2022Peer-reviewedMolecular Biology

Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

Bingbing He, Wenbo Peng, Jia Huang, Hang Zhang, Yingsi Zhou, Xiali Yang, Jing Liu, Zhijie Li, Chunlong Xu, Mingxing Xue, Hui Yang, Pengyu Huang

This study demonstrates the use of CasRx-mediated RNA knockdown to modulate metabolic genes in mouse liver, showing efficient and reversible reduction of PCSK9 and cholesterol levels.

Protein & Cell · Mar 18, 2020Peer-reviewedGenomics

High-fidelity base editor with no detectable genome-wide off-target effects

Erwei Zuo, Yidi Sun, Tanglong Yuan, Bingbing He, Changyang Zhou, Wenqin Ying, Jing Liu, Wei Wu, Rong Zeng, Yixue Li, Hui Yang

The paper identifies base editor variants with reduced off-target effects on both DNA and RNA.

bioRxiv · Feb 7, 2020 · PreprintGenomics