Linyu Shi

This paper develops two deaminase-free base editors, gTBE and gCBE, for direct T and C editing using engineered UNG variants, achieving high editing efficiencies in human cells.

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

This study uses interspecies blastocyst complementation to generate functional rat-derived forebrain tissues in mice, revealing developmental and xenogeneic barriers.

This study shows that Ptbp1 knockdown in mouse striatum using an AAV-based system does not induce astrocyte-to-neuron conversion, contrasting previous reports.