Xuchen Wang

Development of deaminase-free T-to-S base editor and C-to-G base editor by engineered human uracil DNA glycosylase

This paper develops two deaminase-free base editors, gTBE and gCBE, for direct T and C editing using engineered UNG variants, achieving high editing efficiencies in human cells.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effect

The paper designs high-fidelity Cas13 variants with minimal collateral RNA degradation effects, validated in mammalian cells and transgenic mice.