Precise Estimation of In Vivo Protein Turnover Rates
Jonathon J. O’Brien, Vikram Narayan, Yao Liang Wong, Phillip Seitzer, Celeste M. Sandoval, Nicole Haste, Megan Smith, Ramin Rad, Aleksandr Gaun, Adam Baker, Matthew A. Kukurugya, Baby Martin-McNulty, Chunlian Zhang, Ganesh A. Kolumam, Carmela Sidrauski, , Rochelle Buffenstein
This paper introduces a new framework to estimate in vivo protein turnover rates by addressing labeling identification and amino acid enrichment challenges, revealing differences in protein turnover between mice and naked mole-rats.
bioRxiv · Nov 10, 2020 · PreprintBioinformatics