Author

Alan Chu

Scripps Research InstituteORCID 0000-0002-6669-9649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Danielle Ann GrotjahniD· 1 shared Kristen A. JohnsoniD· 1 shared Mashiat ZamaniD· 1 shared Meera PannikkatiD· 1 shared Nicole MadrazoiD· 1 shared Prakhyat MathuriD· 1 shared Prerona BoraiD· 1 shared R. Luke WisemaniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Danielle Ann GrotjahnORCID

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1 paper

Recent·Most cited

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells

Prerona Bora, Mashiat Zaman, Samantha Oviedo, Sergei Kutseikin, Nicole Madrazo, Prakhyat Mathur, Meera Pannikkat, Sophia Krasny, Rama Aldakhlallah, Alan Chu, Kristen A. Johnson, Danielle Ann Grotjahn, Timothy E. Shutt, R. Luke Wiseman

The paper identifies two compounds that activate the HRI pathway, improving mitochondrial function in MFN2-deficient cells.

Proceedings of the National Academy of Sciences · Nov 25, 2025Peer-reviewedCell Biology